Principal Investigator
David F. Tate, Ph.D. (profile link)
Associate Professor, Research
Missouri Institute of Mental Health
University of Missouri, St. Louis
PI: Brain Imaging and Behavior Laboratory
Project Vision/Summary
The Brain Imaging and Behavior Laboratory at the University of Missouri, St. Louis aims to use state of the art medical imaging acquisition and analysis methods to examine the diagnostic and prognostic value of these methods in characterizing the pathological, clinical, and functional outcomes of patients who have suffered a brain injury. Our vision is to provide clinicians with the most relevant imaging biomarkers that could improve the understanding of changes associated with injury and inform treatment in patient specific ways.
These projects bring together researchers and clinicians from multiple disciplines and institutions to address complicated clinical questions. Disciplines include but are not limited to neurology, neuroscience, neuropsychology, computer science, medical physics, mathematics, physical medicine and rehabilitation, etc. Institutions involved include Brooke Army Medical Center, Harvard Medical School, University of Southern California, University of California Los Angeles, Virginia Commonwealth University, Baylor College of Medicine, and others.
Project Goals
Our projects currently include several studies funded by the Department of Defense and include samples of active duty military and veteran participants with and with-out traumatic brain injury.
These studies are designed to:
1. Improve our understanding of the biological consequences of traumatic brain injury and other comorbid disorders such as post-traumatic stress disorder.
2. To track the effects of cognitive rehabilitative treatments using medical imaging and cognitive/behavioral measures
3. To develop more patient centric methods that will improve personalize medicine approaches to treatment in clinically heterogeneous neurological patient populations.
Figure 1. Heat maps of subcortical brain structures showing the surface features that demonstrate the greatest atrophy in TBI patients when compared to healthy non-injured controls (hot colors showing the greatest differences).
Figure 2. Diffusion imaging tracts showing the regions that are significantly different between group of patients with TBI and PTSD.
Acknowledgements
Scientific Collaborators:
Elisabeth Wilde, Ph.D. Baylor College of Medicine and theMicheal DeBakey VA Hospital in Houston, TX
Erin D. Bigler, Ph.D. Brigham Young University
David Cifu, MD Virginia Commonwealth University
COL Sidney Hinds, MD United States Military Research and Material Command
Paul Thompson, Ph.D. University of Southern California
Martha Shenton, Ph.D. Brigham and Women’s Hospital, Harvard Medical School
Sylvia Bouix, Ph.D. Brigham and Women’s Hospital, Harvard Medical School
Inga Koerte, MD Brigham and Women’s Hospital, Harvard Medical School
Emily Dennis, Ph.D. University of Southern California
Douglas Cooper, Ph.D. Brooke Army Medical Center and the Defense and Veterans Brain Injury Center
Amy Bowles, MD Brooke Army Medical Center
Carissa Philippi, Ph.D. University of Missouri, St. Louis
Funding Agencies:
US Army Medical Research and Materials Command
National Institutes of Health
Department of Defense
Recent Representative References
1. Tate DF, Gusman M, Kini J, Reid M, Velez CS, Drennon AM, Cooper DB, Kennedy JE, Bowles AO, Bigler ED, Lewis JD, Ritter J, York GE. Susceptibility Weighted Imaging and White Matter Abnormality Findings in Service Members with Persistent Cognitive Symptoms Following Mild Traumatic Brain Injury. Military Medicine Mar 2017, Vol. 182, No. 3, pp. e1651-e1658.
2. Reid MW, Hannemann NP, York GE, Ritter JL, Kini JA, Lewis JD, Sherman PM, Velez CS, Drennon AM, Bolzenius JD, Tate DF. Comparing Two Processing Pipelines to Measure Subcortical and Cortical Volumes in Patients with and without Mild Traumatic Brain Injury. J Neuroimaging. 2017 Feb 14. PMID: 28194831.
3. Tate DF, Bolzenius JD, Velez CS, Wilde EA, Bouix S, Jaramillo CA, Lewis JD, Weisend M. Assessing the structural and functional effects of neuromodulation using magnetic resonance imaging. Technology and Innovation. 2016 Vol. 18:39-50.
4. Tate DF, Wade BS, Velez CS, Drennon AM, Bolzenius J, Gutman BA, Thompson PM, Lewis JD, Wilde EA, Bigler ED, Shenton ME, Ritter JL, York GE. Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury. J Neurol. 2016 Oct;263(10):2065-79. PMID: 27435967.
5. Cooper DB, Bunner AE, Kennedy JE, Balldin V, Tate DF, Eapen BC, Jaramillo CA. Treatment of persistent postconcussive symptoms after mild traumatic brain injury: a systematic review of cognitive rehabilitation and behavioral health interventions in military service members and veterans. Brain Imaging Behav. 2015 Sep;9(3):403-20. doi: 10.1007/s11682-015-9440-2. PubMed PMID: 26330376.
6. Jaramillo CA, Cooper DB, Wang CP, Tate DF, Eapen BC, York GE, Pugh MJ. Subgroups of US IRAQ and Afghanistan veterans: associations with traumatic brain injury and mental health conditions. Brain Imaging Behav. 2015 Sep;9(3):445-55. doi: 10.1007/s11682-015-9402-8. PubMed PMID: 25963862.